Mind as origin

शरलोमा तु नेत्याह न ह्यात्माऽऽत्मानमात्मना॥

योजयेद्व्याधिभिः दुःखैः दुःखद्वेषी कदाचन॥१०॥

रजस्तमोभ्यां तु मनः परीतम् सत्त्वसंज्ञकम्॥

शरीरस्य समुत्पत्तौ विकाराणां च कारणम्॥११॥

Translation: Sharaloma said " No, Soul cannot be cause of diseases as Soul abhors sorrow and it will not cause sorrow to itself.

(I propose) Mind, also called as Sattva, which is occluded by Rajas and Tamas is the origin of body as well as diseases"

Commentary (Chakrapani): Sattva is the term used for mind to distinguish it from Soul as Manas which is responsible for thought includes both mind and soul.

Commentary (Vishnu): Sharaloma's refutation of Soul as a cause is a very good point. If we take Soul as representing free will( see commentary on previous verses) then such a soul will not willingly become a cause of disease. 

As to his proposal that Mind is the cause of body the argument is not convincing at all. Mind may be the cause of identity remaining intact in spite of continuously changing molecules and cells but it cannot be a cause of body. Manas is described by Charak as a substance beyond Panchamahabhootas or different from panchamahabhootas just like Time or Directions खादीन्यात्मा मनः कालो दिशश्च द्रव्यसंग्रहः॥while Sushruta says that for all practical purposes Manas should be considered as Panchabhoutik सर्वम् द्रव्यम् पांचभौतिकम् अस्मिन्नर्थे॥ If it is taken as beyond panchamahabhootas then it cannot be a cause of Panchabhoutik body.

Its panchabhoutik status described by Sushruta is a virtual status. As mind is affected by Panchabhoutik food or drugs it can be considered Panchabhotik for all practical purposes but it is a deemed or virtual status.

Mind as a cause of diseases is much more convincing as Mind under influence of Rajas or Tamas or both is responsible for behaviors which lead to diseases. Some people say that disease first occurs in mind and then it is manifested in the body. There is always a psychological component to every disease which decides the prognosis. How we cope with the disease depends upon the psyche. But of course it cannot be a sole cause.