List of Hotamisligil Lab publications from: http://www.lablife.org/labs/
[A more exhaustive list can be had by parsing PubMed.]
Yang L, Li P, Fu S, Calay ES, Hotamisligil GS
Cell Metab. 2010 Jun 9. 11(6):467-478.
Li P, Hotamisligil GS
Nature. 2010 Apr 29. 464(7293):1287-8.
Hotamisligil GS
Cell. 2010 Mar 19. 140(6):900-17.
Nakamura T, Furuhashi M, Li P, Cao H, Tuncman G, Sonenberg N, Gorgun CZ, Hotamisligil GS
Cell. 2010 Feb 5. 140(3):338-48.
Hotamisligil GS
Int J Obes (Lond). 2008 Dec . 32 Suppl 7():S52-4.
Gregor MF, Yang L, Fabbrini E, Mohammed BS, Eagon JC, Hotamisligil GS, Klein S
Diabetes. 2009 Mar . 58(3):693-700.
Hotamisligil GS, Erbay E
Nat Rev Immunol. 2008 Dec . 8(12):923-34.
Cao H, Gerhold K, Mayers JR, Wiest MM, Watkins SM, Hotamisligil GS
Cell. 2008 Sep 19. 134(6):933-44.
Vallerie SN, Furuhashi M, Fucho R, Hotamisligil GS
PLoS ONE. 2008 . 3(9):e3151.
J Clin Invest. 2008 Jul . 118(7):2640-50.
Furuhashi M, Hotamisligil GS
Nat Rev Drug Discov. 2008 Jun . 7(6):489-503.
Ozcan U, Ozcan L, Yilmaz E, Düvel K, Sahin M, Manning BD, Hotamisligil GS
Mol Cell. 2008 Mar 14. 29(5):541-51.
Hotamisligil GS
Novartis Found Symp. 2007 . 286():86-94; discussion 94-8, 162-3
Erbay E, Cao H, Hotamisligil GS
Curr Atheroscler Rep. 2007 Sep . 9(3):222-9.
Gregor MF, Hotamisligil GS
J Lipid Res. 2007 Sep . 48(9):1905-14.
Furuhashi M, Tuncman G , Görgün CZ, Makowski L, Atsumi G, Vaillancourt E, Kono K, Babaev VR, Fazio S, Linton MF, Sulsky R, Robl JA, Parker RA,Hotamisligil GS
Nature. 2007 Jun 21. 447(7147):959-65.
Gregor MG, Hotamisligil GS
J Lipid Res. 2007 May 9. ():.
Wellen KE, Fucho R, Gregor MF, Furuhashi M, Morgan C, Lindstad T, Vaillancourt E, Gorgun CZ, Saatcioglu F, Hotamisligil GS
Cell. 2007 May 4. 129(3):537-48.
Ozcan U, Yilmaz E, Ozcan L, Furuhashi M, Vaillancourt E, Smith RO, Görgün CZ, Hotamisligil GS
Science. 2006 Aug 25. 313(5790):1137-40.
Proc Natl Acad Sci U S A. 2006 Jul 11. 103(28):10741-6.
Cao H, Maeda K, Gorgun CZ, Kim HJ, Park SY, Shulman GI, Kim JK, Hotamisligil GS
Diabetes. 2006 Jul . 55(7):1915-22.
Proc Natl Acad Sci U S A. 2006 May 2. 103(18):6970-5.
Hotamisligil GS
Diabetes. 2005 Dec . 54 Suppl 2():S73-8.
Makowski L, Hotamisligil GS
Curr Opin Lipidol. 2005 Oct . 16(5):543-8.
Tsai J, Tong Q, Tan G, Chang AN, Orkin SH, Hotamisligil GS
EMBO Rep. 2005 Sep . 6(9):879-84.
Wellen KE, Hotamisligil GS
J Clin Invest. 2005 May . 115(5):1111-9.
Makowski L, Brittingham KC, Reynolds JM, Suttles J, Hotamisligil GS
J Biol Chem. 2005 Apr 1. 280(13):12888-95.
Tong Q, Tsai J, Tan G, Dalgin G, Hotamisligil GS
Mol Cell Biol. 2005 Jan . 25(2):706-15.
Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, Tuncman G , Görgün C, Glimcher LH, Hotamisligil GS
Science. 2004 Oct 15. 306(5695):457-61.
Makowski L, Hotamisligil GS
J Nutr. 2004 Sep . 134(9):2464S-2468S.
Wellen KE, Uysal KT, Wiesbrock S, Yang Q, Chen H, Hotamisligil GS
Endocrinology. 2004 May . 145(5):2214-20.
Hotamisligil GS
Int J Obes Relat Metab Disord. 2003 Dec . 27 Suppl 3():S53-5.
Tong Q, Tsai J, Hotamisligil GS
Drug News Perspect. 2003 Nov . 16(9):585-8.
Wellen KE, Hotamisligil GS
J Clin Invest. 2003 Dec . 112(12):1785-8.
Maeda K, Uysal KT, Makowski L, Görgün CZ, Atsumi G, Parker RA, Brüning J, Hertzel AV, Bernlohr DA, Hotamisligil GS
Diabetes. 2003 Feb . 52(2):300-7.
Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2117-22. Epub 2008 Feb 5.
Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine at Shanghai Jiao Tong University, Shanghai 200240, China.
PMID: 18252821 [PubMed - indexed for MEDLINE]PMCID: PMC2538887Free PMC Article
Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism
Cao H, Gerhold K, Mayers JR, Wiest MM, Watkins SM, Hotamisligil GS.
Cell. 2008 Sep 19;134(6):933-44.
Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA.
Comment in:
* Cell. 2008 Sep 19;134(6):914-6.
Abstract
Dysregulation of lipid metabolism in individual tissues leads to systemic disruption of insulin action and glucose metabolism. Utilizing quantitative lipidomic analyses and mice deficient in adipose tissue lipid chaperones aP2 and mal1, we explored how metabolic alterations in adipose tissue are linked to whole-body metabolism through lipid signals. A robust increase in de novo lipogenesis rendered the adipose tissue of these mice resistant to the deleterious effects of dietary lipid exposure. Systemic lipid profiling also led to identification of C16:1n7-palmitoleate as an adipose tissue-derived lipid hormone that strongly stimulates muscle insulin action and suppresses hepatosteatosis. Our data reveal a lipid-mediated endocrine network and demonstrate that adipose tissue uses lipokines such as C16:1n7-palmitoleate to communicate with distant organs and regulate systemic metabolic homeostasis.
PMID: 18805087
Symbiotic gut microbes modulate human metabolic phenotypes.
Li M, Wang B, Zhang M, Rantalainen M, Wang S, Zhou H, Zhang Y, Shen J, Pang X, Zhang M, Wei H, Chen Y, Lu H, Zuo J, Su M, Qiu Y, Jia W, Xiao C,Smith LM, Yang S, Holmes E, Tang H, Zhao G, Nicholson JK, Li L, Zhao L.Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine at Shanghai Jiao Tong University, Shanghai 200240, China.
Abstract
Humans have evolved intimate symbiotic relationships with a consortium of gut microbes (microbiome) and individual variations in the microbiome influence host health, may be implicated in disease etiology, and affect drug metabolism, toxicity, and efficacy. However, the molecular basis of these microbe-host interactions and the roles of individual bacterial species are obscure. We now demonstrate a"transgenomic" approach to link gut microbiome and metabolic phenotype (metabotype) variation. We have used a combination of spectroscopic, microbiomic, and multivariate statistical tools to analyze fecal and urinary samples from seven Chinese individuals (sampled twice) and to model the microbial-host metabolic connectivities. At the species level, we found structural differences in the Chinese family gut microbiomes and those reported for American volunteers, which is consistent with population microbial cometabolic differences reported in epidemiological studies. We also introduce the concept of functional metagenomics, defined as "the characterization of key functional members of the microbiome that most influence host metabolism and hence health." For example, Faecalibacterium prausnitzii population variation is associated with modulation of eight urinary metabolites of diverse structure, indicating that this species is a highly functionally active member of the microbiome, influencing numerous host pathways. Other species were identified showing different and varied metabolic interactions. Our approach for understanding the dynamic basis of host-microbiome symbiosis provides a foundation for the development of functional metagenomics as a probe of systemic effects of drugs and diet that are of relevance to personal and public health care solutions.Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism
Cao H, Gerhold K, Mayers JR, Wiest MM, Watkins SM, Hotamisligil GS.
Cell. 2008 Sep 19;134(6):933-44.
Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA.
Comment in:
* Cell. 2008 Sep 19;134(6):914-6.
Abstract
Dysregulation of lipid metabolism in individual tissues leads to systemic disruption of insulin action and glucose metabolism. Utilizing quantitative lipidomic analyses and mice deficient in adipose tissue lipid chaperones aP2 and mal1, we explored how metabolic alterations in adipose tissue are linked to whole-body metabolism through lipid signals. A robust increase in de novo lipogenesis rendered the adipose tissue of these mice resistant to the deleterious effects of dietary lipid exposure. Systemic lipid profiling also led to identification of C16:1n7-palmitoleate as an adipose tissue-derived lipid hormone that strongly stimulates muscle insulin action and suppresses hepatosteatosis. Our data reveal a lipid-mediated endocrine network and demonstrate that adipose tissue uses lipokines such as C16:1n7-palmitoleate to communicate with distant organs and regulate systemic metabolic homeostasis.
PMID: 18805087
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